Send us your paper safety data sheets and well professionally scan and convert them to pdf format before indexing them. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. Pfizer inc believes that the information contained in this material safety data sheet is accurate, and while it is provided in good faith, it is without warranty of any kind, expressed or implied. This document has been prepared in accordance with standards for workplace safety, which require the inclusion of all known hazards of the active substance or its intermediates. Paclitaxel 6 mgml concentrate for solution for infusion. Paclitaxel injection, usp is available in 30 mg 5 ml, 100 mg 16. Data supplied is for use only in connection with occupational safety and health.
Our msds database is an easy to use, do it yourself tool, and best of all. Paclitaxel api dmfs us drug master file dmf details. Paclitaxel taxol is a potent antineoplastic and antimitotic taxane compound used in cancer chemotherapy. Search the australian register of therapeutic goods. Paclitaxel is a white to offwhite crystalline powder with the empirical formula. This document has been prepared in accordance with standards for workplace safety, which require the inclusion of all.
Paclitaxel is a substrate of the drug efflux transporter pglycoprotein pgp and of the hepatic isoenzyme cyp3a4. The cell cycle arrest effect of pac medchem express hyb0015. Paclitaxel for injection contains ethanol absolute alcohol, 396 mgml. If you have had an allergic reaction to paclitaxel you may be given paclitaxel combined with a protein.
If data for a hazard are not included in this document there is no known information at this time. Contact of undiluted concentrate with plasticized pvc equipment or devices is not recommended. Nov 06, 2014 your new online msds binder is a place for you to store the material safety data sheets you need to deploy. Paclitaxel also dysregulates the epithelialtomesenchymal emt transition, inducing transition of cancer cells into benign fibroblastlike cells.
All patients should be premedicated prior to receiving this drug to prevent severe hypersensitivity reactions. For the firstline treatment of nonsmall cell lung cancer in. This product is not classified as toxic by established criteria. Material safety data sheet prepared according to 29 cfr 1910. Paclitaxel is commercially available as proteinbound particles consisting of paclitaxel bound to albumin. The microtubule dysfunction induced by paclitaxel results in aberrant cell mitosis and. Cell signaling technology 3 trask lane danvers, ma 0 923 usa ix. Paclitaxel can cause both mitotic arrest and apoptotic cell death. Dermal 2,000 mgkg based on an assessment of the ingredients.
Nabpaclitaxel versus solventbased paclitaxel in patients. Health hazards paclitaxel is a natural product with antitumor activity. Material safety data sheet paclitaxel injection sost. The recommended dose of ramucirumab is 8 mgkg on days 1 and 15 of a 28 day cycle, prior to paclitaxel infusion. Pronounced in vivo antitumor efficacy of oral paclitaxel nanoemulsion in solid tumor bearing model.
H361 suspected of damaging fertility or the unborn child. Download msdsmaterial safety data sheet of paclitaxel. Jan 02, 2020 if you are 65 or older, use paclitaxel conventional with care. Although noninferiority of nab paclitaxel every 3 weeks to weekly solventbased paclitaxel for overall survival was not confirmed, progressionfree survival and objective responses were similar in both groups of patients. This product information was approved at the time this auspar was published. Since paclitaxel injection is a flammable solution, remove all sources of ignition. Paclitaxel ptx, sold under the brand name taxol among others, is a chemotherapy medication used to treat a number of types of cancer. If abraxane lyophilized cake or reconstituted suspension contacts the skin, wash the skin immediately and thoroughly with soap and water. Paclitaxel with polyoxyethylated castor oil injection.
Although this interaction has not been studied, predictions about the interaction can be made based on the metabolic pathway of paclitaxel. Absorb solution with activated charcoal or absorbent pads. Consult the manufacturer product information or local protocol for premedication guidelines. Women must use birth control while taking paclitaxel conventional. During all fire fighting activities, wear appropriate protective equipment, including self contained breathing apparatus. Albuminbound paclitaxel is a sterile, white to yellow lyophilized powder that must be reconstituted for. Abraxane is a cytotoxic drug and, as with other potentially toxic paclitaxel compounds, caution should be exercised in handling abraxane. Standard operating procedure for paclitaxel taxol in animals. Each single use vial contains 100 mg of paclitaxel and 900 mg. Abraxane powder for injection suspension abraxis bioscience australia pty ltd.
Oct 28, 2016 paclitaxel injection, usp is a clear, colorless to slightly yellow viscous solution. Administer through iv tubing containing an inline 0. Formation of toxic gases is possible during heating or fire. Hazards identification classification of the substance or mixture. Paclitaxel belongs to the taxane family of antitumor and antileukemic agents 3. Jan 24, 2019 5 mgm2 iv over 24 hours followed by cisplatin every 3 weeks. Standard operating procedure for paclitaxel taxol in animals 1. Paclitaxel, diluted in culture medium, is added in quadruplicate wells and the cells ae incubated for 3 days before mts reagents are added to quantitate the live cells in each well. Albuminbound paclitaxel is a sterile, white to yellow lyophilized powder that must be reconstituted for use as an injectable suspension. Paclitaxel investigated as a drug, mutagen, reproductive effector, and tumorigen. Appropriate management of complications is possible only when adequate diagnostic and treatment facilities are readily available. Box 697, osprey, florida, 342290697 941 3779935 fax 941 3779539 cas number 67630. Please consult the material safety data sheet for information regarding hazards and safehandling practices. Identification of the substancemixture and of the company.
H334 may cause allergy or asthma symptoms or breathing difficulties if inhaled. Page 1 of 5 patient agreement to systemic anticancer therapy. In vitro, paclitaxel induces caspase 8mediated apoptosis through the association of caspase 8s death effector domain with microtubules. Paclitaxel paclitaxel dose, indications, adverse effects. In an in vitro angiogenesis assay, paclitaxel at ultra low concentrations blocks human ecs from forming sprouts and tubes in the threedimensional fibrin matrix. Paclitaxel taxol is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization. Handling and storage handling advice on safe handling. Paclitaxel is a novel antimicrotubule agent that promotes the assembly of microtubules. However, we make no warranty of merchantibility or any other warranty, express or implied. We aimed to investigate the efficacy and safety of nab paclitaxel versus solventbased paclitaxel in patients with previously treated advanced gastric cancer. Feb 20, 2014 paclitaxel taxol, one of the most important anticancer drugs, has been used for therapy of different types of cancers. The recommended dose of paclitaxel is 80 2mgm administered by intravenous infusion over approximately 60 minutes on days 1, 8 and 15 of a 28 day cycle.
Paclitaxel hazard statements h315 causes skin irritation. If inhaled if breathed in, move person into fresh air. It is supplied as a nonaqueous solution intended for dilution with a suitable parenteral fluid prior to intravenous infusion. Avastin bevacizumab, in combination with carboplatin and paclitaxel, is indicated for the firstline treatment of patients with unresectable advanced, recurrent or metastatic nsclc. Weve included the most sought after safety data sheets. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. Women of childbearing potential receiving paclitaxel should be advised to avoid becoming pregnant, and to inform the treating physician immediately should this occur. Taxol paclitaxel injection for dilution is supplied as a nonaqueous clear, colourless to slightly yellow viscous solution intended for dilution with a suitable parenteral fluid prior to intravenous infusion. Paclitaxel with polyoxyethylated castor oil injection comes as a liquid to be injected over 3 or 24 hours intravenously by a doctor or nurse in a hospital or clinic. Skin contact may cause burning sensation, stinging, itching and tingling. Preparation instructions paclitaxel is soluble in dmso 50 mgml. List of drug master files dmf of paclitaxel active pharmaceutical ingredient api submitted to the u.
Flammable liquid and vapor keep away from ignition sources and clean up spills promptly. Paclitaxel page 2 of 3 developed by danafarber cancer institute last revised 052018 patient and family education committee 5. The submission of this msds may be required by law, but this is not an assertion that the substance is hazardous when used in accordance with proper safety practices and normal handling procedures. The information herein is based on data considered to be accurate as of the date of preparation of this material safety data sheet. Paclitaxel is obtained via a semisynthetic process from taxus baccata. Paclitaxel when it is given in combination with a platinum compound, e. Online account customers can also search by invoice number, order.
Paclitaxel injection, usp safety data sheet sds effective date. May cause irritation, redness, inflammation or dryness. Paclitaxel is the generic nonbranded name of the drug, but you may hear it called by one of its brand names such as taxol. Direct contact with eyes may cause temporary irritation. Additionally, higher doses of nab paclitaxel can be administered over a shorter infusion time and at higher drug concentrations compared with solventbased paclitaxel. Nab paclitaxel every 3 weeks was associated with more frequent toxicities than weekly solventbased paclitaxel. Abraxane is supplied as a white to yellow, sterile, lyophilised cake for reconstitution in a 50 ml clear type i glass vial with a latex free, bromo butyl rubber stopper, individually packaged in a carton. Precautionary statements p201 obtain special instructions before use. Dispose of contentscontainer to an approved waste disposal plant. Paclitaxel name of proposed course of treatment include brief explanation if medical term not clear paclitaxel chemotherapy for the treatment of breast cancer. Administer corticosteroids, h1antagonists, h2 antagonists, prior to paclitaxel administration to minimize potential for anaphylaxis.
In the presence of smf, the efficient concentration of paclitaxel on k562 cells is decreased from 50 to 10 ngml. H361 suspected of damaging fertility or the unborn. The 28day toxicity study of the nanoemulsion proved to be a viable media to deliver paclitaxel. Analytical data hnmr consistent with structure hplc shows 99. Paclitaxel represented a mean of 5% of the administered radioactivity recovered in the feces, while metabolites, primarily 6.
Taxol paclitaxel dosing, indications, interactions, adverse. Sds of paclitaxel side chain acid, safety data sheets, cas. Pharmaceutical product antineoplastic details of the supplier of the safety data sheet 2. Taxane relevant identified uses of the substance or mixture and uses advised against intended use. View indentification, hazards, safety information, toxicity, regulations. Paclitaxel 6 mgml concentrate for solution for infusion should not be used during pregnancy unless the clinical condition of the woman requires treatment with paclitaxel. Abraxane for injectable suspension paclitaxel proteinbound. Paclitaxel c47h51no14 c47h51no14 853,91 gmol concentration casno. Taxol paclitaxel injection rx only patient information included warning taxol paclitaxel should be administered under the supervision of a physician experienced in the use of cancer chemotherapeutic agents.
Buy 7epi 10desacetyl paclitaxel cas 78454178, a paclitaxel impurity which may inhibit cancer cell growth, from santa cruz. Material safety datasheet 9sections section 1 product information product identifier drytype transformer whmis classification optional product use electrical manufacturers name hammond power solutions inc. When paclitaxel with polyoxyethylated castor oil is used to treat breast cancer, ovarian cancer, or nonsmall cell lung cancer it is usually given once every 3 weeks. Cells including human neonatal dermal microvascular ecs hmvecs, human umbilical vein ecs huvecs, human.
Page 1 7 material safety data sheet issuing date 10apr2011 revision date 1jan20 revision number 1 1. None of the components is considered a reproductive hazard. Understanding and correcting msds file upload errors. Sds lookup this page helps you find, save and then print sds sheets.
This includes ovarian cancer, breast cancer, lung cancer, kaposi sarcoma, cervical cancer, and pancreatic cancer. However, no warranty or representation, expressed or implied, is made as to the accuracy or completeness of the foregoing data and safety information. Show this safety data sheet to the doctor in attendance. Product and company identification product name sortkwik recommended use apply to fingers to improve grip for filing and sorting. This document has been prepared in accordance with standards for workplace safety, which requires the inclusion of all known hazards of the product or its ingredients regardless of the. Paclitaxel is a potent antineoplastic and antimitotic taxane drug, which binds to the n. See actual entry in rtecs for complete information. You can search by item code, sds code or manufacturer code.
It is highly lipophilic, insoluble in water, and melts at around 216217 c. Mechanistically, paclitaxel arrests cell cycle and induces cell death by stabilizing microtubules and interfering with microtubule disassembly in cell division. If you wish to search by description, please use the site search feature. Sigmaaldrich offers a number of paclitaxel products.
Product information for auspar abraxane paclitaxel nab abraxis pm20152314 date of finalisation 17 june 2014. Understanding and correcting msds file upload errors during the file upload process in msds, users will often receive a popup message indicating the file was uploaded successfully, yet sometimes the data never reaches the staging area. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Highlights of prescribing information these highlights do not include all the information needed to use taxotere safely and effectively. Only select registry of toxic effects of chemical substances rtecs data is presented here.
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